Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/92518
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Type: | Journal article |
Title: | Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules |
Author: | Liang, K. Ricco, R. Doherty, C. Styles, M. Bell, S. Kirby, N. Mudie, S. Haylock, D. Hill, A. Doonan, C. Falcaro, P. |
Citation: | Nature Communications, 2015; 6(1):1-8 |
Publisher: | Nature Publishing Group |
Issue Date: | 2015 |
ISSN: | 2041-1723 2041-1723 |
Statement of Responsibility: | Kang Liang, Raffaele Ricco, Cara M. Doherty, Mark J. Styles, Stephen Bell, Nigel Kirby, Stephen Mudie, David Haylock, Anita J. Hill, Christian J. Doonan, Paolo Falcaro |
Abstract: | Enhancing the robustness of functional biomacromolecules is a critical challenge in biotechnology, which if addressed would enhance their use in pharmaceuticals, chemical processing and biostorage. Here we report a novel method, inspired by natural biomineralization processes, which provides unprecedented protection of biomacromolecules by encapsulating them within a class of porous materials termed metal-organic frameworks. We show that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules. The resulting biocomposite is stable under conditions that would normally decompose many biological macromolecules. For example, urease and horseradish peroxidase protected within a metal-organic framework shell are found to retain bioactivity after being treated at 80 °C and boiled in dimethylformamide (153 °C), respectively. This rapid, low-cost biomimetic mineralization process gives rise to new possibilities for the exploitation of biomacromolecules. |
Keywords: | Chemical sciences Inorganic chemistry Nanotechnology |
Rights: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material |
DOI: | 10.1038/ncomms8240 |
Grant ID: | http://purl.org/au-research/grants/arc/DE120102451 http://purl.org/au-research/grants/arc/DE140101359 |
Published version: | http://dx.doi.org/10.1038/ncomms8240 |
Appears in Collections: | Aurora harvest 7 Psychology publications |
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hdl_92518.pdf | Published version | 2.23 MB | Adobe PDF | View/Open |
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