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https://hdl.handle.net/2440/97548
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Type: | Journal article |
Title: | An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis |
Author: | Geake, J. Reid, D. Currie, B. Bell, S. Bright-Thomas, R. Dewar, J. Holden, S. Simmonds, N. Gyi, K. Kenna, D. Waters, V. Jackson, M. O'Sullivan, B. Taccetti, G. Kolbe, J. O'Carroll, M. Campbell, D. Jaksic, M. Radhakrishna, N. Kidd, T. et al. |
Citation: | BMC Pulmonary Medicine, 2015; 15(1):116-1-116-10 |
Publisher: | BioMed Central |
Issue Date: | 2015 |
ISSN: | 1471-2466 1471-2466 |
Statement of Responsibility: | James B. Geake, David W. Reid, Bart J. Currie, Scott C. Bell, and MelioidCF Investigators |
Abstract: | Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies.We performed a literature search to identify all published cases of B. pseudomallei infection in CF. In addition we hand-searched respiratory journals, and contacted experts in infectious diseases and CF around the world. Supervising clinicians for identified cases were contacted and contemporaneous clinical data was requested.25 culture-confirmed cases were identified. The median age at acquisition was 21 years, mean FEV1 % predicted was 60 %, and mean BMI was 19.5 kg/m(2). The location of acquisition was northern Australia or south-east Asia for most. 19 patients (76 %) developed chronic infection, which was usually associated with clinical decline. Successful eradication strategies included a minimum of two weeks of intravenous ceftazidime, followed by a consolidation phase with trimethoprim/sulfamethoxazole, and this resulted in a higher chance of success when instituted early. Three cases of lung transplantation have been recorded in the setting of chronic B. pseudomallei infection.Chronic carriage of B. pseudomallei in patients with CF appears common after infection, in contrast to the non-CF population. This is often associated with an accelerated clinical decline. Lung transplantation has been performed in select cases of chronic B. pseudomallei infection. |
Keywords: | MelioidCF Investigators |
Rights: | © 2015 Geake et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
DOI: | 10.1186/s12890-015-0109-9 |
Published version: | http://dx.doi.org/10.1186/s12890-015-0109-9 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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hdl_97548.pdf | Published version | 489.71 kB | Adobe PDF | View/Open |
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