Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/99485
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy |
Author: | Sime, F.B. Roberts, M.S. Warner, M.S. Hahn, U. Robertson, T.A. Yeend, S. Phay, A. Lehman, S. Lipman, J. Peake, S.L. Roberts, J.A. |
Citation: | Antimicrobial Agents and Chemotherapy, 2014; 58(6):3533-3537 |
Publisher: | American Society for Microbiology |
Issue Date: | 2014 |
ISSN: | 0066-4804 1098-6596 |
Statement of Responsibility: | Fekade Bruck Sime, Michael S. Roberts, Morgyn S. Warner, Uwe Hahn, Thomas A. Robertson, Sue Yeend, Andy Phay, Sheila Lehman, Jeffrey Lipman, Sandra L. Peake, Jason A. Roberts |
Abstract: | This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7 ± 8.0 liters [mean ± standard deviation]) and clearance (20.2 ± 7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure. |
Keywords: | Humans Hematologic Neoplasms Neutropenia Fever Piperacillin Anti-Bacterial Agents Aged Middle Aged Female Male |
Rights: | Copyright © 2014, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/AAC.02340-14 |
Published version: | http://dx.doi.org/10.1128/aac.02340-14 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.