Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/162312
Title: | Functional effects of the buckwheat iminosugar D-fagomine on rats with diet-induced prediabetes |
Author: | Ramos Romero, Sara Hereu, Mercè Atienza, Lidia Casas, Josefina Taltavull, Núria Romeu Ferran, Marta Amézqueta, Susana Dasilva, Gabriel Medina, Isabel Torres, Josep Lluís |
Keywords: | Microbiota Diabetis Obesitat Microbiota Diabetes Obesity |
Issue Date: | 2018 |
Publisher: | Wiley-VCH |
Abstract: | Scope: The goals of this work were to test if D-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action. Methods and results: Wistar Kyoto rats were fed a high-fat diet supplemented with D7 fagomine (or not; for comparison) or a standard diet (controls) for 24 weeks. The variables measured were: fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue, liver and muscle; inflammation markers (plasma IL-6 and leptin, and liver and adipose tissue histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales and Bifidobacteriales in feces. We found that D-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 and leukotriene B4) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales. Conclusion: D-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of D-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201800373 |
It is part of: | Molecular Nutrition & Food Research, 2018, vol. 62, num. 16, p. 1800373 |
URI: | http://hdl.handle.net/2445/162312 |
Related resource: | https://doi.org/10.1002/mnfr.201800373 |
ISSN: | 1613-4125 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
683721.pdf | 688.81 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.