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https://hdl.handle.net/2445/176303
Title: | Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila |
Author: | Camilleri Robles, Carlos Serras Rigalt, Florenci Corominas, Montserrat (Corominas Guiu) |
Keywords: | Proteïnes G ADN Drosòfila G Proteins DNA Drosophila |
Issue Date: | 18-May-2019 |
Publisher: | MDPI |
Abstract: | The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/genes10050378 |
It is part of: | Genes, 2019, vol. 10, num. 5, p. 378 |
URI: | https://hdl.handle.net/2445/176303 |
Related resource: | https://doi.org/10.3390/genes10050378 |
ISSN: | 2073-4425 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut de Biomedicina (IBUB)) |
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