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https://hdl.handle.net/2445/186538
Title: | Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration |
Author: | Esteban-Collado, José Corominas, Montserrat (Corominas Guiu) Serras Rigalt, Florenci |
Keywords: | Drosòfila Creixement Insulina Regeneració (Biologia) Drosophila Growth Insulin Regeneration (Biology) |
Issue Date: | 23-Apr-2021 |
Publisher: | The Company of Biologists |
Abstract: | Regeneration after damage requires early signals to trigger the tissue repair machinery. Reactive oxygen species (ROS) act as early signals that are sensed by the MAP3 kinase Ask1, which in turn activates by phosphorylation the MAP kinases p38 and JNK. The sustained or high activation of these kinases can result in apoptosis, whereas short or low activation can promote regeneration. Using the Ask1-dependent regeneration program, we demonstrate in Drosophila wing that PI3K/Akt signaling is necessary for Ask1 to activate p38, but not JNK. In addition, nutrient restriction or mutations that target Ser83 of the Drosophila Ask1 protein, a PI3K/Akt-sensitive residue, block regeneration. However, these effects can be reversed by the ectopic activation of p38, but not of JNK. Our results demonstrate that Ask1 controls the activation of p38 through Ser83, and that the phosphorylation of p38 during regeneration is nutrient sensitive. This mechanism is important for discriminating between p38 and JNK in the cells involved in tissue repair and regenerative growth. |
Note: | Reproducció del document publicat a: https://doi.org/10.1242/dev.197087 |
It is part of: | Development, 2021, vol. 148, num. 8, p. 1-7 |
URI: | https://hdl.handle.net/2445/186538 |
Related resource: | https://doi.org/10.1242/dev.197087 |
ISSN: | 0950-1991 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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File | Description | Size | Format | |
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716076.pdf | 6.42 MB | Adobe PDF | View/Open |
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