University of Illinois at Chicago
Browse
Varhegyi_Elizabeth.pdf (1.58 MB)

Analysis of Viral Entry Factors and Discovery of Anti-filoviral Entry Inhibitors

Download (1.58 MB)
thesis
posted on 2016-07-01, 00:00 authored by Elizabeth A. Varhegyi
Emerging viral diseases, such as those caused by H5N1 avian influenza and the filoviruses Ebola and Marburg virus, are often difficult to predict and can lead to severe illness and death. It is important to study these viruses so we can best know how to combat them. In this work, we investigate both the basic mechanism of infection for H5N1 influenza virus, Ebola, and Marburg virus, and to develop effective anti-filoviral therapeutics. Here we demonstrate that the reticulon 4 receptor (RTN4R) plays a role in influenza infection, while the tropomyosin receptor kinase B (TrkB) is involved in filoviral infection. We also report several small molecule compounds and plant extracts which exhibit potent anti-filoviral activity.

History

Advisor

Rong, Lijun

Department

Microbiology & Immunology

Degree Grantor

University of Illinois at Chicago

Degree Level

  • Doctoral

Committee Member

Freitag, Nancy He, Bin Shukla, Deepak Caffrey, Michael

Submitted date

2016-05

Language

  • en

Issue date

2016-07-01

Usage metrics

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC