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Steroid degradation in Comamonas testosteroni.
http://hdl.handle.net/10069/24613
http://hdl.handle.net/10069/2461336fbd10d-466f-49d9-8a95-80e0c5adf62e
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2011-02-09 | |||||||||||
タイトル | ||||||||||||
タイトル | Steroid degradation in Comamonas testosteroni. | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Comamonas testosteroni | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Steroid | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
著者 |
Horinouchi, Masae
× Horinouchi, Masae
× Hayashi, Toshiaki
× Kudo, Toshiaki
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Steroid degradation by Comamonas testosteroni and Nocardia restrictus have been intensively studied for the purpose of obtaining materials for steroid drug synthesis. C. testosteroni degrades side chains and converts single/double bonds of certain steroid compounds to produce androsta-1,4-diene 3,17-dione or the derivative. Following 9α-hydroxylation leads to aromatization of the A-ring accompanied by cleavage of the B-ring, and aromatized A-ring is hydroxylated at C-4 position, cleaved at Δ4 by meta-cleavage, and divided into 2-hydroxyhexa-2,4-dienoic acid (A-ring) and 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid (B,C,D-ring) by hydrolysis. Reactions and the genes involved in the cleavage and the following degradation of the A-ring are similar to those for bacterial biphenyl degradation, and 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid degradation is suggested to be mainly β-oxidation. Genes involved in A-ring aromatization and degradation form a gene cluster, and the genes involved in β-oxidation of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid also comprise a large cluster of more than 10 genes. The DNA region between these two main steroid degradation gene clusters contain 3α-hydroxysteroid dehydrogenase gene, Δ5,3-ketosteroid isomerase gene, genes for inversion of an α-oriented-hydroxyl group to a β-oriented-hydroxyl group at C-12 position of cholic acid, and genes possibly involved in the degradation of a side chain at C-17 position of cholic acid, indicating this DNA region of more than 100kb to be a steroid degradation gene hot spot of C. testosteroni. | |||||||||||
書誌情報 |
The Journal of steroid biochemistry and molecular biology 巻 129, 号 1-2, p. 4-14, 発行日 2012-03 |
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出版者 | ||||||||||||
出版者 | Elsevier Ltd. | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 09600760 | |||||||||||
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収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 18791220 | |||||||||||
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収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AA1077779X | |||||||||||
PubMed番号 | ||||||||||||
関連タイプ | isVersionOf | |||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 21056662 | |||||||||||
DOI | ||||||||||||
関連タイプ | isVersionOf | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.1016/j.jsbmb.2010.10.008 | |||||||||||
権利 | ||||||||||||
権利情報 | Copyright © 2010 Elsevier Ltd All rights reserved. | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | AM | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
引用 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | The Journal of steroid biochemistry and molecular biology, 129(1-2), pp.4-14; 2012 |