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Hyperglycemia inhibits recovery from disuse-induced skeletal muscle atrophy in rats
http://hdl.handle.net/10069/35709
http://hdl.handle.net/10069/3570974b9ab7f-70a9-402a-bc1b-eaf9d058ebce
名前 / ファイル | ライセンス | アクション |
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ISYK700_Kataoka.pdf (3.4 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2015-07-30 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Hyperglycemia inhibits recovery from disuse-induced skeletal muscle atrophy in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hyperglycemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Disuse-induced muscle atrophy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Recovery | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
片岡, 英樹
× 片岡, 英樹 |
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著者別名 | ||||||
姓名 | Kataoka, Hideki | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study was to evaluate the effects of hyperglycemia on skeletal muscle recovery following disuse-induced muscle atrophy in rats. Wistar rats were grouped as streptozotocin-induced diabetic rats and non-diabetic rats. Both ankle joints of each rat were immobilized to induce atrophy of the gastrocnemius muscles. After two weeks of immobilization and an additional two weeks of recovery, tail blood and gastrocnemius muscles were isolated. Serial cross sections of muscles were stained for myosin ATPase (pH 4.5) and alkaline phosphatase activity. Serum insulin and muscle insulin-like growth factor-1 (IGF-1) levels were also measured. Serum insulin levels were significantly reduced in the diabetic rats compared to the non-diabetic controls. The diameters of type I, IIa, and IIb myofibers and capillary-to-myofiber ratio in the isolated muscle tissue were decreased after immobilization in both treatments. During the recovery period, these parameters were restored in the non-diabetic rats, but not in the diabetic rats. In addition, muscle IGF-1 levels after recovery increased significantly in the non-diabetic rats, but not in the diabetic rats. We conclude that decreased levels of insulin and IGF-1 and impairment of angiogenesis associated with diabetes might be partly responsible for the inhibition of regrowth in diabetic muscle. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第700号 学位授与年月日:平成26年8月6日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Kataoka H, Nakano J, Morimoto Y, Honda Y, Sakamoto J, Origuchi T, Okita M, Yoshimura T | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: PHYSIOLOGICAL RESEARCH, 63(4), pp.465-474; 2014 | |||||
書誌情報 |
PHYSIOLOGICAL RESEARCH 巻 63, 号 4, p. 465-474, 発行日 2014-08-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18029973 | |||||
権利 | ||||||
権利情報 | c 2014 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 高血糖はラット骨格筋の廃用性筋萎縮の回復を抑制する | |||||
出版者 | ||||||
出版者 | Czech Academy of Sciences | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/34872 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2014-08-06 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第700号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2014-08-06) |