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Effect of metabolic inhibitors on the hepatic disposition of 5-fluorouracil after application to the rat liver surface
http://hdl.handle.net/10069/36262
http://hdl.handle.net/10069/3626289219cc9-1f68-4a4c-8658-9de87ce4c6a2
名前 / ファイル | ライセンス | アクション |
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ISYK858_Shimokawa.pdf (603.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-03-28 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of metabolic inhibitors on the hepatic disposition of 5-fluorouracil after application to the rat liver surface | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver surface | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-fluorouracil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | disposition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dihydropyrimidine dehydrogenase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gimeracil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | uridine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
下川, 研太
× 下川, 研太 |
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著者別名 | ||||||
姓名 | Shimokawa, Kenta | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the effects of 5-fluorouracil (5-FU) metabolic inhibitors, gimeracil or uridine, on the hepatic disposition of 5-FU after application to the liver surface in rats, aiming to enhance the availability of 5-FU in the liver. 5-FU solution with or without metabolic inhibitors was applied to the rat liver surface using a cylindrical diffusion cell. The liver, blood and the remaining solution in the diffusion cell were collected at specified times, and assayed for 5-FU content. 5-FU absorption properties were not altered by addition of gimeracil and uridine. The 5-FU concentration in the diffusion cell attachment site of the rat liver (site 1) at 0.1?0.4?M ratios of gimeracil to 5-FU was significantly higher than that of the control. On the contrary, the addition of uridine did not increase the 5-FU concentration at site 1. At a 0.1?M ratio of gimeracil to 5-FU, the maximum 5-FU plasma concentration was the lowest, and the area under the 5-FU concentration?time curve at site 1 was 3.4 times greater than that of the control. We demonstrated that applying 5-FU with gimeracil to the rat liver surface could increase the availability of 5-FU in the liver. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第858号 学位授与年月日:平成28年3月18日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Kenta Shimokawa, Kazumi Wakasugi, Rei Tomonaga, Ken Utsunomiya, Hirotaka Miyamoto, Shintaro Fumoto, Koyo Nishida | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Biological and Pharmaceutical Bulletin, 39(3), 361-367; 2016 | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 39, 号 3, p. 361-367, 発行日 2016-03-18 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b15-00757 | |||||
権利 | ||||||
権利情報 | (C) 2016 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 肝臓表面投与後の5-fluorouracilの肝内分布に及ぼす代謝阻害剤の影響 | |||||
出版者 | ||||||
出版者 | 日本薬学会 / The Pharmaceutical Society of Japan | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/36523 | |||||
学位名 | ||||||
学位名 | 博士(薬学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-18 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第858号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(薬学) (2016-03-18) |