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Clinical Roles of Interleukin-6 and STAT3 in Oral Squamous Cell Carcinoma
http://hdl.handle.net/10069/37282
http://hdl.handle.net/10069/3728262f5438b-50ff-4353-bf14-6863b6126ac7
名前 / ファイル | ライセンス | アクション |
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ISYK921_Shinagawa.pdf (468.4 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-05-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical Roles of Interleukin-6 and STAT3 in Oral Squamous Cell Carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Il-6 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | STAT3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oral squamous cell carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphangiogenesis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
品川, 兼一
× 品川, 兼一 |
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著者別名 | ||||||
姓名 | Shinagawa, Kenichi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect inflammation has on cancer prognosis is marked by the presence of cytokines and chemokines. Interleukin-6 (IL-6) is one a multifunctional cytokine that regulates inflammatory responses. We investigated the roles of IL-6 and STAT3 and examined the relationship between IL-6 signaling and clinicopathological factors in patients with oral squamous cell carcinoma (OSCC). We retrospectively examined 116 patients who underwent radical surgery for OSCC. IL-6 and STAT3 expression were detected by immunohistochemistry. IL-6 and STAT3 positivity were detected by IHC, at 78.4 and 80.2 %, respectively. IL-6 expression was significantly associated with pattern of invasion (P = 0.004), vascular invasion (P = 0.003), and pathological nodal status (P = 0.019). Multivariate logistic regression analysis revealed that IL-6 expression was significantly associated with vascular invasion (P = 0.044). Meanwhile, there was no significant association between STAT3 expression and clinicopathological factors and no significant relationship between IL-6 and STAT3 expression. IL-6 expression was significantly associated with 5-year disease-free survival. These results suggest that IL-6 is involved in lymphangiogenesis and recurrence in OSCC. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第921号 学位授与年月日:平成29年3月21日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Kenichi Shinagawa, Souichi Yanamoto, Tomofumi Naruse, Akiko Kawakita, Kota Morishita, Yuki Sakamoto, Satoshi Rokutanda, Masahiro Umeda | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Pathology & Oncology Research, 23(2), pp.425-431; 2017 | |||||
書誌情報 |
Pathology & Oncology Research 巻 23, 号 2, p. 425-431, 発行日 2017-03-21 |
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DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12253-016-0134-x | |||||
権利 | ||||||
権利情報 | c Aranyi Lajos Foundation 2016 | |||||
権利 | ||||||
権利情報 | The original publication is available at link.springer.com | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 口腔扁平上皮癌におけるInterleukin-6とSTAT3の臨床的役割 | |||||
出版者 | ||||||
出版者 | Springer Netherlands | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-03-21 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第921号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(歯学) (2017-03-21) |