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MicroRNA-130a is highly expressed in the esophageal mucosa of esophageal achalasia.
http://hdl.handle.net/10069/37606
http://hdl.handle.net/10069/37606ecc108dc-2aa2-4928-bf44-566d9b7dc085
名前 / ファイル | ライセンス | アクション |
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ISYK852_Shoji.pdf (616.2 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-07-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | MicroRNA-130a is highly expressed in the esophageal mucosa of esophageal achalasia. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | esophageal achalasia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | etiology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microRNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peroral endoscopic myotomy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | esophageal cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
庄司, 寛之
× 庄司, 寛之 |
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著者別名 | ||||||
姓名 | Shoji, Hiroyuki | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Esophageal achalasia is considered as a risk factor of esophageal cancer. The etiologies of esophageal achalasia remain unknown. Peroral endoscopic myotomy (POEM) has recently been established as a minimally invasive method with high curability. The aims of the present study were to identify the microRNAs (miRs) specific to esophageal achalasia, to determine their potential target genes and to assess their alteration following POEM. RNA was extracted from biopsy samples from middle esophageal mucosa and analyzed using a microarray. Differentially expressed miRs in achalasia patients compared with control samples were identified and analyzed using reverse transcription?quantitative polymerase chain reaction (RT?qPCR). Correlations between specific miR expression levels and the patients' clinical background were also investigated. In addition, alterations of selected miR expression levels before and after POEM were analyzed. The results of RT?qPCR analysis demonstrated that the miR?130a expression levels were significantly higher in patients with achalasia (P<0.0001). In addition, miR?130a expression was significantly correlated with male sex and smoking history in patients with achalasia. However, no significant change in miR?130a expression was observed between before and after POEM. In conclusion, miR?130a is highly expressed in the esophageal mucosa of patients with achalasia and may be a biomarker of esophageal achalasia. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第852号 学位授与年月日:平成28年3月18日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Hiroyuki Shoji, Hajime Isomoto, Akira Yoshida, Haruo Ikeda, Hitomi Minami, Tsutomu Kanda, Shigetoshi Urabe, Kayoko Matsushima, Fuminao Takeshima, Kazuhiko Nakao, Haruhiro Inoue | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Experimental and Therapeutic Medicine, 14(2), pp.898-904; 2017 | |||||
書誌情報 |
Experimental and Therapeutic Medicine 巻 14, 号 2, p. 898-904, 発行日 2016-03-18 |
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DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/etm.2017.4598 | |||||
権利 | ||||||
権利情報 | c Shoji et al. This is an open access article distributed under the terms of Creative Commons Attribution License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 食道アカラシア患者の食道粘膜においてmicroRNA130a 発現は亢進している | |||||
出版者 | ||||||
出版者 | Spandidos Publications | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/36517 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-18 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第852号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2016-03-18) |