Whole-genome sequence of Schistosoma haematobium
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Author(s)
Young, Neil D
Jex, Aaron R
Li, Bo
Liu, Shiping
Yang, Linfeng
Xiong, Zijun
Li, Yingrui
Cantacessi, Cinzia
Hall, Ross S
Xu, Xun
Chen, Fangyuan
Wu, Xuan
Zerlotini, Adhemar
Oliveira, Guilherme
Hofmann, Andreas
Zhang, Guojie
Fang, Xiaodong
Kang, Yi
Campbell, Bronwyn E
Loukas, Alex
Ranganathan, Shoba
Rollinson, David
Rinaldi, Gabriel
Brindley, Paul J
Yang, Huanming
Wang, Jun
Wang, Jian
Gasser, Robin B
Griffith University Author(s)
Year published
2012
Metadata
Show full item recordAbstract
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide1. No vaccines are available, and treatment relies on one drug, praziquantel2. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer1,3 and as a predisposing factor for HIV/AIDS4,5. The parasite is transmitted to humans from freshwater snails1. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease6 and induce squamous cell carcinoma7. ...
View more >Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide1. No vaccines are available, and treatment relies on one drug, praziquantel2. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer1,3 and as a predisposing factor for HIV/AIDS4,5. The parasite is transmitted to humans from freshwater snails1. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease6 and induce squamous cell carcinoma7. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites8,9. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.
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View more >Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide1. No vaccines are available, and treatment relies on one drug, praziquantel2. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer1,3 and as a predisposing factor for HIV/AIDS4,5. The parasite is transmitted to humans from freshwater snails1. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease6 and induce squamous cell carcinoma7. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites8,9. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.
View less >
Journal Title
Nature Genetics
Volume
44
Issue
2
Copyright Statement
© 2012 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
Subject
Biological sciences
Structural biology (incl. macromolecular modelling)
Biomedical and clinical sciences