学位論文

界面活性剤を用いた水媒体中でのアズレン誘導体の合成反応

ASYNTHETIC REACTION OF AZULENE DERIVATIVES IN AN AQUEOUS MEDIUM IN THE PRESENCE OF ASURFACTANT

jpn

2009-03-24

Not Applicable (or Unknown)

2009-03-24

修士(工学)

工学研究科物質化学専攻; 指導教授: 中村暢男

Owing to the increasing environmental concerns, organic reactions in an aqueous medium with no use of organic solvents have attracted continuing attention. Although water, as a reaction medium, is generally recognized as a cheap, safe, and environmentally benign alternative to unnatural solvents, it has not yet been widely accepted for synthetic purposes simply due to the poor solubility of organic compounds in it. Thus many studies on organic reactions in water have been carried out in the presence of a small amount of a surfactant which is known to provide an excellent hydrophobic reaction field. Moreover, combination of surfactant abilities such as dispersion and protection of organic compounds with catalytic activity such as that of a Lewis acid has been rigorously devised to result in the formation, for instance, of a Lewis acid-surfactant combined catalyst. However, the reactivity dependence on the nature of surfactants has little been studied. Herein we report dehydration reactions in water in the presence of a surfactant with both hydrophilic and hydrophobic groups and one-pot synthesis of some azulene amide derivatives in water with the added surfactants of either kinds, i.e. anion or cation ones for the comparison of their effects on the reactivity. It has now been observed that the product yield in water has been improved in the presence of these surfactants.

Thesis