Repeated implantation of skeletal myoblast in a swine model of chronic myocardial infarction

Gavira, J.J. (Juan José); Nasarre, E. (Emilio); Abizanda-Sarasa, G. (Gloria); Perez-Ilzarbe, M. (Maitane); Martino-Rodriguez, A. (Alba) de; Garcia-de-Jalon, J.A. (José A.); Mazo, M. (Manuel); Macias, A. (Alfonso); Garcia-Bolao, I. (Ignacio); Pelacho, B. (Beatriz); Martinez-Caro, D. (Diego); Prosper-Cardoso, F. (Felipe)

Keywords:

Stem cell
Myoblast
Myocardial infarction
Animal model
Swine

Issue Date:

2010

Publisher:

Oxford University Press

Project:

222995 - INFARCT CELL THERAPY - Therapy after heart infarct: prevention of reperfusion injury and repair by stem cell transfer

ISSN:

0195-668X

Citation:

Gavira, J. J., Nasarre, E., Abizanda, G., Perez-Ilzarbe, M. et al. Repeated implantation of skeletal myoblast in a swine model of chronic myocardial infarction.Eur. Heart J. (2010); 31: 1013–1021

Abstract

Although transplantation of skeletal myoblast (SkM) in models of chronic myocardial infarction (MI) induces an improvement in cardiac function, the limited engraftment remains a major limitation. We analyse in a pre-clinical model whether the sequential transplantation of autologous SkM by percutaneous delivery was associated with increased cell engraftment and functional benefit.

URI:

https://hdl.handle.net/10171/18159

Appears in Collections:

DA - CIMA - Hemato-oncología - Síndromes mieloproliferativos - Artículos de Revista
DA - CIMA - Medicina regenerativa - Terapia celular - Artículos de Revista
DA - CUN - Área de Terapia Celular - Artículos de revista

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