Trehalose-based siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

Carbajo-Gordillo, A.I. (Ana I.); Rodríguez-Lavado, J. (Julio); Jiménez-Blanco, J.L. (José Luis); Benito, J.M. (Juan M.); Di-Giorgio, C. (Christophe); Vélaz-Rivas, I. (Icíar); Tros-de-Ilarduya, C. (Conchita); Ortiz-Mellet, C. (Carmen); García-Fernández, J.M. (José M.)

Keywords:

Materias Investigacion::Farmacia
Materias Investigacion::Química

Issue Date:

2019

Publisher:

Royal Society of Chemistry

ISSN:

1359-7345

Note:

This article is licensed under a Creative Commons Atribution 3.0 unported

Citation:

Carbajo-Gordillo, A.I. (Ana I.); Rodríguez-Lavado, J. (Julio); Jiménez-Blanco, J.L. (José Luis); et al. "Trehalose-based siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties". Chemical communications. 55, 2019, 8227 - 8230

Abstract

An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared fromthe disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.

URI:

https://hdl.handle.net/10171/58669

DOI:

https://doi.org/10.1039/C9CC04489B
10.1039/C9CC04489B

Appears in Collections:

DA - Ciencias - Química - Artículos de revista
DA - Farmacia - Tecnología Farmacéutica - Artículos de revista

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