Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/120335
Author(s): | Fonseca E. Ruivo R. Lopes-Marques M. Zhang H. Santos M.M. Venkatesh B. Castro L.F.C. |
Title: | LXRα and LXRβ nuclear receptors evolved in the common ancestor of gnathostomes |
Publisher: | Oxford University Press |
Issue Date: | 2017 |
Abstract: | Nuclear receptors (NRs) regulate numerous aspects of the endocrine system. They mediate endogenous and exogenous cues, ensuring a homeostatic control of development and metabolism. Gene duplication, loss and mutation have shaped the repertoire and function of NRs in metazoans. Here, we examine the evolution of a pivotal orchestrator of cholesterol metabolism in vertebrates, the liver X receptors (LXRs). Previous studies suggested that LXRα and LXRβ genes emerged in themammalian ancestor. However, we show through genomean alysis and functional assay that bona fide LXRα and LXRβ orthologues are present in reptiles, coelacanth and chondrichthyans but not in cyclostomes. These findings show that LXR duplicated before gnathostome radiation, followed by asymmetric paralogue loss in some lineages. We suggest that a tighter control of cholesterol levels in vertebrates was achieved through the exploitation of a wider range of oxysterols, an ability contingent on ligand-binding pocket remodeling. © 2016 The Author. |
Subject: | cholesterol helminth protein liver X receptor animal chemistry classification genetics Gnathostoma lipid metabolism metabolism molecular evolution phylogeny Animals Cholesterol Evolution, Molecular Gnathostoma Helminth Proteins Lipid Metabolism Liver X Receptors Phylogeny |
URI: | https://hdl.handle.net/10216/120335 |
Source: | Genome Biology and Evolution, vol. 9(1), p. 222-230 |
Related Information: | info:eu-repo/grantAgreement/FCT/5876/147268/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | CIIMAR - Artigo em Revista Científica Internacional |
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File | Description | Size | Format | |
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Fonseca E_2017.pdf Restricted Access | 1.36 MB | Adobe PDF | Request a copy |
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