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Título: | Label-free bacteria quantification in blood plasma by a bioprinted microarray based interferometric point-of-care device |
Autor: | Dey, Priyanka; Fabri-Faja, Nuria CSIC ORCID; Calvo-Lozano, Olalla CSIC ORCID; Terborg, Roland A.; Belushkin, Alexander; Yesilköy, Filiz; Fàbrega, Anna; Ruiz-Rodriguez, Juan Carlos; Ferrer, Ricard; González-López, Juan José; Estévez, M. Carmen CSIC ORCID ; Altug, Hatice; Pruneri, Valerio; Lechuga, Laura M. CSIC ORCID | Fecha de publicación: | 2019 | Editor: | American Chemical Society | Citación: | ACS Sensors 4(1): 52-60 (2019) | Resumen: | Existing clinical methods for bacteria detection lack speed, sensitivity, and, importantly, point-of-care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. Here we report a portable PoC device based on lens-free interferometric microscopy (LIM). The device employs high performance nanoplasmonics and custom bioprinted microarrays and is capable of direct label-free bacteria ( E. coli) quantification. With only one-step sample handling we offer a sample-to-data turnaround time of 40 min. Our technology features detection sensitivity of a single bacterial cell both in buffer and in diluted blood plasma and is intrinsically limited by the number of cells present in the detection volume. When employed in a hospital setting, the device has enabled accurate categorization of sepsis patients (infectious SIRS) from control groups (healthy individuals and noninfectious SIRS patients) without false positives/negatives. User-friendly on-site bacterial clinical diagnosis can thus become a reality. | Versión del editor: | https://doi.org/10.1021/acssensors.8b00789 | URI: | http://hdl.handle.net/10261/200631 | DOI: | 10.1021/acssensors.8b00789 | E-ISSN: | 2379-3694 |
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