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Título: | Characterization of human thioredoxin-like-1: Potential involvement in the cellular response against glucose deprivation |
Autor: | Jiménez, Alberto CSIC ORCID CVN; Pelto-Huikko, Markku; Gustafsson, Jan-Åke; Miranda-Vizuete, Antonio CSIC ORCID | Palabras clave: | Thioredoxin Glucose deprivation Cell death Stress |
Fecha de publicación: | 19-ene-2006 | Editor: | Elsevier Federation of European Biochemical Societies |
Citación: | FEBS Letters 580(3): 960-967 (2006) | Resumen: | The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance. Thioredoxin-like-1 (TXL-1) is a highly conserved protein comprising an N-terminal Trx domain and a C-terminal domain of unknown function. Here we show that TXL-1 is a substrate for the cytosolic selenoprotein TrxR-1. In situ hybridization experiments demonstrates high expression of Txl-1 mRNA in various areas of central nervous system and also in some reproductive organs. Glucose deprivation, but not hydrogen peroxide treatment, reduced the levels of endogenous TXL-1 protein in HEK-293 cell line. Conversely, overexpression of TXL-1 protects against glucose deprivation-induced cytotoxicity. Taken together, the finding that Txl-1 mRNA is highly expressed in tissues which use glucose as a primary energy source and the modulation of TXL-1 levels upon glucose deprivation indicate that TXL-1 might be involved in the cellular response to sugar starvation stress. | Descripción: | 27 páginas, 6 figuras. Datos suplementarios. | Versión del editor: | http://dx.doi.org/10.1016/j.febslet.2006.01.025 | URI: | http://hdl.handle.net/10261/46508 | DOI: | 10.1016/j.febslet.2006.01.025 | ISSN: | 0014-5793 | E-ISSN: | 1873-3468 |
Aparece en las colecciones: | (CABD) Artículos (IMB) Artículos |
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