Item Details

title

The Association of Celecoxib, Rofecoxib, and Non-selective NSAIDs with Indices of Thrombosis and Endothelial Function in the Multi-Ethnic Study of Atherosclerosis

author

Allen, Stewart

abstract

Cyclooxygenase-2 (COX-2) inhibitors and non-selective nonsteroidal anti-inflammatory medications (NSAIDs) have been associated with increased cardiovascular risk. It is the intent of this discussion to explore mechanisms by which celecoxib, rofecoxib, and nonselective anti-inflammatory medications influence cardiovascular risk. Specifically, I will present data from the Multi-Ethnic Study of Atherosclerosis in order to identify an association of nonsteroidal anti-inflammatory medications with indices of thrombosis and endothelial function. It is my hope that this discussion will lead to a more complete understanding of the cardiovascular risk associated with this class of medications that has had a dramatic effect on public health.

subject

COX-2 inhibitors

NSAID

thrombosis

endothelial function

contributor

Furberg, Curt (committee chair)

Chen, Haiying (committee member)

Herrington, David (committee member)

Sane, David (committee member)

date

2009-06-04T18:53:50Z (accessioned)

2010-06-18T18:57:43Z (accessioned)

2009-06-04T18:53:50Z (available)

2010-06-18T18:57:43Z (available)

2009-06-04T18:53:50Z (issued)

degree

Clinical Epidemiology & Health Services (discipline)

identifier

http://hdl.handle.net/10339/14708 (uri)

language

en_US (iso)

publisher

Wake Forest University

rights

Release the entire work immediately for access worldwide. (accessRights)

type

Thesis