Item Details

title

Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer

author

Graham, Elizabeth Grace

abstract

Nanoparticle mediated photothermal ablation of cancer is a promising technique that utilizes light energy to destroy cancer cells. Specifically, nanoparticles that absorb in the near infrared (NIR) region of light, 700 - 900 nm, are optimal because these wavelengths are an absorption minimum for water, hemoglobin, and deoxygenated hemoglobin. As these wavelengths are where tissues are most transparent, NIR photothermal therapies allow for efficacious localized hyperthermia. Our lab has recently utilized poly[4,4-bis(2-ethylhexyl)-cyclopenta[2,1-b;3,4-b']dithiophene-2,6-diyl-alt−2,1,3-benzoselenadiazole-4,7-diyl] (PCPDTBSe), a conjugated polymer, to form nanoparticles capable of generating effective photothermal ablation when stimulated by NIR light.

subject

cancer

fluorescence

near infrared

photothermal therapy

polymer nanoparticle

theranostic

contributor

Levi-Polyachenko, Nicole H (committee chair)

Mohs, Aaron M (committee member)

Stewart IV, John H (committee member)

Singh, Ravi N (committee member)

Metheny-Barlow, Linda J (committee member)

Bickford, Lissett R (committee member)

date

2015-06-23T08:35:59Z (accessioned)

2016-06-22T08:30:10Z (available)

2015 (issued)

degree

Biomedical Engineering (discipline)

embargo

2016-06-22 (terms)

identifier

http://hdl.handle.net/10339/57185 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation