Item Details

title

QUANTITATIVE DETECTION OF LIVER-RELEVANT BIOMARKERS BY SERS-IMMUNOLABALED GOLD NANOPARTICLES

author

Payne, William Mark

abstract

Lab-on-a-chip technology has the potential to rapidly change the way experiments are conducted in a variety of fields ranging from medicine to environmental science. Specifically, sensors, detectors, and monitoring devices are increasingly being miniaturized to perform many experiments or measurements on a single chip. In this research, we develop an immunolabeled gold nanoparticle complex capable of detecting liver organoid biomarkers intended for use in a microfluidic device. Human Serum Albumin (HSA) and α-Glutathione S-Transferase (α-GST) are liver biomarkers that indicate liver health and damage respectively. Herein we demonstrate

subject

biosensing

biosensor

Gold nanoparticles

lab-on-a-chip

plasmonics

contributor

Mohs, Aaron M (committee chair)

Levi, Nicole H (committee member)

date

2015-08-25T08:35:28Z (accessioned)

2015-08-25T08:35:28Z (available)

2015 (issued)

degree

Biomedical Engineering (discipline)

identifier

http://hdl.handle.net/10339/57254 (uri)

language

en (iso)

publisher

Wake Forest University

type

Thesis