Item Details

title

TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO

author

McCabe, Eleanor

abstract

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and the fourth most common cancer in the United States. When CRC disseminates into the abdominal cavity, there can be hundreds, if not thousands, of small tumors infiltrating the surfaces of organs, making it extremely difficult to treat by conventional methods. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in combination with cytoreductive surgery (CRS) has improved the 5-year survival rate of late-stage CRC patients from 12% to 51%. However, the survival rates of these patients have stagnated, which emphasizes the need for more innovative approaches to improve patient survival outcomes.

subject

Colorectal Cancer

HIPEC

Photothermal Therapy

Polymer Nanoparticles

Theranostic

Tissue Phantoms

contributor

Levi-Polyachenko, Nicole H (committee chair)

Stewart, John H (committee member)

Wagner, William D (committee member)

Seeds, Michael C (committee member)

Mohs, Aaron M (committee member)

date

2018-05-24T08:36:13Z (accessioned)

2020-05-23T08:30:16Z (available)

2018 (issued)

degree

Molecular Medicine and Translational Science (discipline)

embargo

2020-05-23 (terms)

identifier

http://hdl.handle.net/10339/90738 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation