Item Details

title

OSTEOARTHRITIS PROMOTES PROSTATE CANCER PROGRESSION

author

Rosas, Samuel

abstract

Introduction: Cancer is the second greatest cause of death in the United States. Furthermore, an estimated 31,000 deaths occur annually affecting the quality of life of those who survive it. Therefore, great interest has been directed at identifying treatable risk factors that could decrease the incidence or the progression of this debilitating disease. The purpose of this dissertation was to evaluate whether osteoarthritis, an enormously prevalent disease, affected the prostate cancer patients. The molecular basis of this association lies in research that uncovered that prostate cancer tumors expressing cartilage oligomeric matrix protein (COMP) have worse outcomes compared to tumors not overexpressing this protein. COMP is found in high concentrations in the serum of patients with osteoarthritis and as such may be the link between these two conditions.

subject

arthritis

arthroplasty

biology

correlation

prostate cancer

contributor

Willey, Jeffrey S (committee chair)

Willey, Jeffrey S (committee member)

Kerr, Bethany A (committee member)

Emory, Cynthia L (committee member)

Smith, Thomas L (committee member)

Tallant, E. Ann (committee member)

Yammani, Raghunatha (committee member)

date

2020-05-29T08:35:32Z (accessioned)

2020-05-29T08:35:32Z (available)

2020 (issued)

degree

Molecular Medicine and Translational Science (discipline)

identifier

http://hdl.handle.net/10339/96788 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation