Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/140615
Title: | Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes | Authors: | Limwongyut, Jakarin Liu, Yang Chilambi, Gayatri Shankar Seviour, Thomas Hinks, Jamie Mu, Yuguang Bazan, Guillermo C. |
Keywords: | Engineering::Bioengineering | Issue Date: | 2018 | Source: | Limwongyut, J., Liu, Y., Chilambi, G. S., Seviour, T., Hinks, J., Mu, Y., & Bazan, G. C. (2018). Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes. RSC Advances, 8(70), 39849-39853. doi:10.1039/c8ra08069k | Journal: | RSC Advances | Abstract: | A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, compared to its linear analog (COE2-3C), COE2-3-pCp introduces more lipid disorder with higher extent of membrane thinning. COE2-3-pCp also exhibits a higher MIC towards E. coli K12 and yeast, while maintaining similar levels of membrane permeabilization. These findings suggest a new design of COEs as biocompatible cell permeabilizers. | URI: | https://hdl.handle.net/10356/140615 | ISSN: | 2046-2069 | DOI: | 10.1039/C8RA08069K | Schools: | School of Chemical and Biomedical Engineering School of Biological Sciences |
Research Centres: | Singapore Centre for Environmental Life Sciences and Engineering | Rights: | © 2018 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes.pdf | 648.78 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
50
8
Updated on Mar 25, 2024
Web of ScienceTM
Citations
20
7
Updated on Oct 24, 2023
Page view(s)
212
Updated on Mar 28, 2024
Download(s) 50
55
Updated on Mar 28, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.