Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/162029
Title: | Activatable molecular probes for second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging | Authors: | Huang, Jiaguo Pu, Kanyi |
Keywords: | Engineering::Chemical engineering | Issue Date: | 2020 | Source: | Huang, J. & Pu, K. (2020). Activatable molecular probes for second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging. Angewandte Chemie International Edition, 59(29), 11717-11731. https://dx.doi.org/10.1002/anie.202001783 | Project: | M4081627 2017-T1-002-134 RG147/17 2019-T1-002-045 MOE2018-T2-2-042 RG125/19 |
Journal: | Angewandte Chemie International Edition | Abstract: | Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650-900 nm, conventional optical imaging often has a poor signal-to-background ratio and shallow penetration depth, which limits its ability in deep-tissue in vivo imaging. Second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near-infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep-tissue imaging are also discussed. | URI: | https://hdl.handle.net/10356/162029 | ISSN: | 1433-7851 | DOI: | 10.1002/anie.202001783 | Schools: | School of Chemical and Biomedical Engineering | Rights: | © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SCBE Journal Articles |
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