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https://hdl.handle.net/10356/86696
Title: | Nanoparticle regrowth enhances photoacoustic signals of semiconducting macromolecular probe for in vivo imaging | Authors: | Xie, Chen Zhen, Xu Lyu, Yan Pu, Kanyi |
Keywords: | Photoacoustic Imaging Polymer Nanoparticles |
Issue Date: | 2017 | Source: | Xie, C., Zhen, X., Lyu, Y., & Pu, K. (2017). Nanoparticle Regrowth Enhances Photoacoustic Signals of Semiconducting Macromolecular Probe for In Vivo Imaging. Advanced Materials, 29(44), 1703693-. | Series/Report no.: | Advanced Materials | Abstract: | Smart molecular probes that emit deep-tissue penetrating photoacoustic (PA) signals responsive to the target of interest are imperative to understand disease pathology and develop innovative therapeutics. This study reports a self-assembly approach to develop semiconducting macromolecular activatable probe for in vivo imaging of reactive oxygen species (ROS). This probe comprises a near-infrared absorbing phthalocyanine core and four poly(ethylene glycol) (PEG) arms linked by ROS-responsive self-immolative segments. Such an amphiphilic macromolecular structure allows it to undergo an ROS-specific cleavage process to release hydrophilic PEG and enhance the hydrophobicity of the nanosystem. Consequently, the residual phthalocyanine component self-assembles and regrows into large nanoparticles, leading to ROS-enhanced PA signals. The small size of the intact macromolecular probe is beneficial to penetrate into the tumor tissue of living mice, while the ROS-activated regrowth of nanoparticles prolongs the retention along with enhanced PA signals, permitting imaging of ROS during chemotherapy. This study thus capitalizes on stimuli-controlled self-assembly of macromolecules in conjunction with enhanced heat transfer in large nanoparticles for the development of smart molecular probes for PA imaging. | URI: | https://hdl.handle.net/10356/86696 http://hdl.handle.net/10220/44170 |
ISSN: | 0935-9648 | DOI: | 10.1002/adma.201703693 | Schools: | School of Chemical and Biomedical Engineering | Rights: | © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Materials, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/adma.201703693]. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles |
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Nanoparticle regrowth enhances photoacoustic signals of semiconducting macromolecular probe for in vivo imaging.pdf | 6.13 MB | Adobe PDF | View/Open |
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