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https://hdl.handle.net/10356/89831
Title: | The role of PPARβ/δ in melanoma metastasis | Authors: | Lim, Jonathan Chee Woei Kwan, Yuet Ping Tan, Michelle Siying Teo, Melissa Hui Yen Chiba, Shunsuke Wahli, Walter Wang, Xiaomeng |
Keywords: | Peroxisome Proliferator–activated Receptor β/δ DRNTU::Science::Biological sciences::Biochemistry Melanoma |
Issue Date: | 2018 | Source: | Lim, J. C. W., Kwan, Y. P., Tan, M. S., Teo, M. H. Y., Chiba, S., Wahli, W., & Wang, X. (2018). The role of PPARβ/δ in melanoma metastasis. International Journal of Molecular Sciences, 19(10), 2860-. doi:10.3390/ijms19102860 | Series/Report no.: | International Journal of Molecular Sciences | Abstract: | Background: Peroxisome proliferator–activated receptor (PPAR) β/δ, a ligand-activated transcription factor, is involved in diverse biological processes including cell proliferation, cell differentiation, inflammation and energy homeostasis. Besides its well-established roles in metabolic disorders, PPARβ/δ has been linked to carcinogenesis and was reported to inhibit melanoma cell proliferation, anchorage-dependent clonogenicity and ectopic xenograft tumorigenicity. However, PPARβ/δ’s role in tumour progression and metastasis remains controversial. Methods: In the present studies, the consequence of PPARβ/δ inhibition either by global genetic deletion or by a specific PPARβ/δ antagonist, 10h, on malignant transformation of melanoma cells and melanoma metastasis was examined using both in vitro and in vivo models. Results: Our study showed that 10h promotes epithelial-mesenchymal transition (EMT), migration, adhesion, invasion and trans-endothelial migration of mouse melanoma B16/F10 cells. We further demonstrated an increased tumour cell extravasation in the lungs of wild-type mice subjected to 10h treatment and in Pparβ/δ−/− mice in an experimental mouse model of blood-borne pulmonary metastasis by tail vein injection. This observation was further supported by an increased tumour burden in the lungs of Pparβ/δ−/− mice as demonstrated in the same animal model. Conclusion: These results indicated a protective role of PPARβ/δ in melanoma progression and metastasis. | URI: | https://hdl.handle.net/10356/89831 http://hdl.handle.net/10220/46371 |
ISSN: | 1661-6596 | DOI: | 10.3390/ijms19102860 | Schools: | School of Physical and Mathematical Sciences Lee Kong Chian School of Medicine (LKCMedicine) |
Rights: | © 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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Melanoma Metastasis.pdf | 3.08 MB | Adobe PDF | View/Open |
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