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Aerosol Delivery of Small Hairpin Osteopontin Blocks Pulmonary Metastasis of Breast Cancer in Mice

Cited 20 time in Web of Science Cited 26 time in Scopus
Authors

Yu, Kyeong-Nam; Minai-Tehrani, Arash; Chang, Seung-Hee; Hwang, Soon-Kyung; Hong, Seong-Ho; Kim, Ji-Eun; Shin, Ji-Young; Park, Sung-Jin; Kim, Ji-Hye; Kwon, Jung-Taek; Jiang, Hu-Lin; Kang, Bitna; Kim, Duyeol; Chae, Chan-Hee; Lee, Kee-Ho; Yoon, Tae-Jong; Beck, George R., Jr.; Cho, Myung-Haing

Issue Date
2010-12
Publisher
Public Library of Science
Citation
PLoS ONE, Vol.5 No.12, p. e15623
Abstract
Background: Metastasis to the lung may be the final step in the breast cancer-related morbidity. Conventional therapies such as chemotherapy and surgery are somewhat successful, however, metastasis-related breast cancer morbidity remains high. Thus, a novel approach to prevent breast tumor metastasis is needed. Methodology/Principal Finding: Aerosol of lentivirus-based small hairpin osteopontin was delivered into mice with breast cancer twice a week for 1 or 2 months using a nose-only inhalation system. The effects of small hairpin osteopontin on breast cancer metastasis to the lung were evaluated using near infrared imaging as well as diverse molecular techniques. Aerosol-delivered small hairpin osteopontin significantly decreased the expression level of osteopontin and altered the expression of several important metastasis-related proteins in our murine breast cancer model. Conclusion/Significance: Aerosol-delivered small hairpin osteopontin blocked breast cancer metastasis. Our results showed that noninvasive targeting of pulmonary osteopontin or other specific genes responsible for cancer metastasis could be used as an effective therapeutic regimen for the treatment of metastatic epithelial tumors.
ISSN
1932-6203
URI
https://hdl.handle.net/10371/172500
DOI
https://doi.org/10.1371/journal.pone.0015623
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