Publications
Detailed Information
Capsaicin suppresses phorbol ester-induced activation of NF-κB/Rel and AP-1 transcription factors in mouse epidermis : Capsaicin suppresses phorbol ester-induced activation of NF-kappa B/Rel and AP-1 transcription factors in mouse epidermis
Cited 91 time in
Web of Science
Cited 104 time in Scopus
- Authors
- Issue Date
- 2001-03
- Publisher
- Elsevier BV
- Citation
- Cancer Letters, Vol.164 No.2, pp.119-126
- Abstract
- Capsaicin, the principal pungent ingredient of hot chili peppers, has anti-inflammatory and analgesic properties and is currently used as a topical cream for the management of various neuropathic conditions. In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of I kappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65. Likewise, phorbol ester-induced activation of activator protein-1 (AP-1) was abolished by capsaicin pretreatment. Since altered transactivation of NF-kappaB and AP-1 has been implicated for neoplastic transformation and progression, the suppression of these transcription factors by capsaicin may account for its previously reported chemopreventive effects on mouse skin tumorigenesis as well as inflammation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
- ISSN
- 0304-3835
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.