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A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naive first-episode mania
Cited 49 time in
Web of Science
Cited 52 time in Scopus
- Authors
- Issue Date
- 2007
- Publisher
- Wiley-Blackwell
- Citation
- Bipolar Disord 2007; 9: 693-697
- Keywords
- Adult ; Age Factors ; Anticonvulsants/therapeutic use ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/diagnosis/drug therapy/*pathology ; Brain/*pathology ; Brain Mapping/methods ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Functional Laterality/*physiology ; Gyrus Cinguli/pathology ; Humans ; Magnetic Resonance Imaging/*statistics & numerical data ; Male ; Psychiatric Status Rating Scales ; Sex Factors
- Abstract
- OBJECTIVES: Patients with bipolar disorder have changes in brain structures but it is unclear if these are present at disease onset and thus predispose subjects to develop the disorder, or whether they develop during the course of the disorder, either due to the effects of multiple episodes or as a consequence of treatment with psychotropic agents. Studies in first-episode (FE) manic patients have the potential to provide answers to these questions. METHODS: Voxel-based morphometry (VBM) was used to assess magnetic resonance imaging scans of 15 FE manic patients and 15 matched healthy controls. RESULTS: Using a priori defined statistical criteria, no significant differences in brain structures were noted between the two groups. However, there was approximately a 6% reduction in left anterior cingulate, left precuneus and right posterior cingulate volume in FE patients and these reductions were significant (p
- ISSN
- 1398-5647 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17988358
https://hdl.handle.net/10371/23168
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