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Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users
Cited 29 time in
Web of Science
Cited 37 time in Scopus
- Authors
- Issue Date
- 2005-10-29
- Publisher
- Elsevier
- Citation
- Drug Alcohol Depend. 2006 Apr 28;82(2):177-81. Epub 2005 Oct 25.
- Keywords
- Adult ; Alcohol Drinking/physiopathology ; Cerebrovascular Circulation/*physiology ; Female ; Functional Laterality ; Gyrus Cinguli/*blood supply ; Humans ; Male ; Reference Values ; Substance-Related Disorders/*physiopathology/radionuclide ; imaging/rehabilitation ; Tomography, Emission-Computed, Single-Photon ; Methamphetamine
- Abstract
- BACKGROUND: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users. METHODS: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethyl-propylene amine oxime ((99m)Tc-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (<6 months) and long-term (>or=6 months) abstinence. RESULTS: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users. CONCLUSIONS: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence.
- ISSN
- 0376-8716 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16253441
https://hdl.handle.net/10371/24681
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