Publications
Detailed Information
Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic mice
Cited 29 time in
Web of Science
Cited 27 time in Scopus
- Authors
- Issue Date
- 2005-06-28
- Publisher
- Elsevier
- Citation
- Brain Res. 2005 Jul 19;1050(1-2):203-9.
- Keywords
- Amyotrophic Lateral Sclerosis/*metabolism/pathology ; Animals ; Astrocytes/*enzymology/pathology ; Central Nervous System/pathology/*physiopathology ; Extracellular Signal-Regulated MAP Kinases/*metabolism ; Immunohistochemistry ; Mice ; Mice, Inbred Strains ; Mice, Transgenic ; Phosphorylation ; Superoxide Dismutase/*genetics
- Abstract
- In the present study, we performed immunohistochemical studies to investigate the changes of phosphorylated extracellular signal-regulated kinases (pERK) in the central nervous system of SOD1(G93A) transgenic mice. In symptomatic transgenic mice, pERK-immunoreactive astrocytes were detected in the spinal cord, brainstem, central gray and cerebellar nuclei. In contrast to symptomatic mice, no pERK-immunoreactive astrocytes were observed in any brain region of wtSOD1 and presymptomatic mice, and the number and intensity of stained neurons were not different at the age of 8 weeks and 13 weeks. Interestingly, region-specific alterations in pERK immunoreactivity were observed in the hippocampal region and cerebellum. These results provide the first evidence that pERK-immunoreactive astrocytes were found in the CNS of SOD1(G93A) transgenic mice after clinical symptoms, showing a possible consequence of the pathological process of ALS. This study has also demonstrated that pERK increases in the hippocampus and cerebellum, suggesting a role of pERK in an abnormality of cognitive and/or motor function in ALS, respectively. However, the mechanisms underlying the increased immunoreactivity for pERK and the functional implications require elucidation.
- ISSN
- 0006-8993 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15978558
https://hdl.handle.net/10371/27581
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.