위의 경계 영역병변(이형상피병변)의 병리학적 특성

Abstract

atypical epithelial lesion of the stomach were examined with authors' modified histo-topographic reconst· ruction method, and their pathologic characteristics were discussed along with its histogenesis. Five out of 7 cases were operated for either early or advanced carcinoma of the stomach, and only two were preoperatively diagnosed by endoscopic biopsy and radiological studies. Average age of the cases was 50.6 years, and majority were found in lower portion of stomach and mostly single in number. The lesions were all under 2.0 em in diameter, ranging from O. 5 em to 2. Oem. Macroscopically, they were sessile, poly paid, global and often mulberry-shaped, but 3 were made of flat and/or slightly depressed lesions. Cellular atypism of grade 1 comprised the bulk, with more prominent nuclear stratification and mitotic figures in the basal portion where they accompanied verrucous gastritis. cystic dilatation or intestinal metaplastic changes of proper glands as their underlying disorders below the lesion. And adjacent gastric mucosa represented a diffuse form of severe metaplastic gastritis. Those figures support that the borderline lesion may develop as a sequential step of dedifferentiated metaplastic gastritis during a reparative process of repeated mucosal erosions of the chronic gastritis.