흰쥐 발정주기간의 수종 장기 혈류량에 미치는 hCG의 영향

Abstract

The blood flows of the uterus. heart and liver were measured by means of "Rb uptake during the estrous cycle of the rats. The effect of hCG administration on the now was also observed. On the day of estrus and diestrus. H<'Rb in the form of chloride. diluted with physiological saline was intravenously injected in less than 5 seconds. The rats were sacrificed after 30 seconds by deca· pitation. 86Rb uptake in about Igrn of each tissue was measured. On the basis of uptake value. administered dose and body weight. the local flow are calculated. Total uterine flow was also derived using the total uterine weight. Followings were the results: I. The fractional uptake of seRb by the uterus at the time of diestrus was similar with the liver and appeared to be much higher than that of the body as a whole. 2. The fractional uptake of "Rb by the uterus showed no significant change during the estrous cycle despite the elevated uterine weight found on the day of estrus. 3. The proportionate uptakes of 86Rb by heart and liver did not appreciably change during the estrous cycle. Following hCG administration. the uptakes by both tissues were also unchanged. 4. hCG injection on the day of proestrus failed to alter the uterine rubidium uptake and weight on the day of estrus. 5. When hCG was injected during the latter half of estrous cycle, an increase in uterine weight occurred. whereas fractional SORb uptake remained unaltered and as a consequence, a significant increase in whole uterine blood flow was observed. 6. Results of this study suggested that: a) A significant effect of hCG on the day of diestrus is probably connected with an increased progesterone secretion. b) The lower blood flow observed on the day of estrus of the rats is probably associated with species differences in patterns of steroid hormone secretion by ovary. c) Unaltered uterine blood flow during the estrous cycle seen in this experiment is probably due to the wide variation on the day of estrus.