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Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus
Cited 34 time in
Web of Science
Cited 33 time in Scopus
- Authors
- Issue Date
- 2007-08-22
- Publisher
- Springer Verlag
- Citation
- Neurochem Res. 33(1):179-184
- Keywords
- Animals ; Blotting, Western ; Hippocampus/*drug effects/metabolism ; Immunohistochemistry ; Interleukin-18/*metabolism ; Kainic Acid/*toxicity ; Male ; Mice ; Mice, Inbred ICR ; Neuroglia/*metabolism ; Receptors, Interleukin-18/*metabolism
- Abstract
- Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we characterized the expressions of IL-18 and IL-18 receptor (IL-18R) in kainic acid (KA)-induced excitotoxicity in mouse hippocampus by immunohistochemistry and Western blotting. IL-18 immunoreactivity was found in microglia whereas IL-18R immunoreactivity was observed in astrocytes. Levels of IL-18 and IL-18R in hippocampus homogenates increased progressively from day 1 post-KA and peaked at 3 days. This study demonstrates the cellular sources of IL-18 and IL-18R, and their temporal correlations after KA-insult, and suggests roles for IL-18 and IL-18R in glial cells in response to excitotoxic damage in the hippocampus.
- ISSN
- 0364-3190 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17710540
http://www.springerlink.com/content/l440771644462741/fulltext.pdf
https://hdl.handle.net/10371/68408
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