Hippocampus를 떼어버린 흰쥐의 Audiogenic Seizure

Abstract

Rats in which the hippocampus was ablated through overlying neocortex(hippoocampus-ablated rats) and rats in which only the portion of neocortex over the hippocampus was ablated(neocortex-ablated rats) were prepared and their susceptibility to the sound produced by one bell("weak" sound. 105~1O7 decibels) or two bells("strong" sound, 110~114 decibels) to induce audiogenic seizure was tested before and after brain ablation. The susceptibility to the sound increased both III hippocampus-ablated rats and in neocortex-ablated animals. While in neocortex-ablated rats the increase in the frequency of audiogenic seizure was manifest only under strong sound. hippocampus-ablated animals showed increased susceptibility to both weak and strong sound.