WEKO3
アイテム
{"_buckets": {"deposit": "db486078-58de-432b-9563-e6f955b5c614"}, "_deposit": {"created_by": 11, "id": "3125", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "3125"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00003125", "sets": ["37"]}, "author_link": [], "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-09-22", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "69", "bibliographicVolumeNumber": "2", "bibliographic_titles": [{"bibliographic_title": "Frontiers in Medicine", "bibliographic_titleLang": "en"}]}]}, "item_6_date_granted_70": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2016-03-10"}]}, "item_6_degree_grantor_68": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "滋賀医科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "14202", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_6_degree_name_67": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background:\nInterleukin (IL)-36 cytokines are recently reported member of the IL-1 cytokine family. However, there is little information regarding the association between IL-36 cytokines and gut inflammation. In the present study, we investigated the biological activity of IL-36α and IL-36γ using human colonic subepithelial myofibroblasts (SEMFs). ", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "Methods:\nThe mRNA expression and the protein expression of target molecules in SEMFs were evaluated using real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The intracellular signaling of IL-36 cytokines was analyzed using Western blot analysis and small interfering RNAs (siRNAs) specific for MyD88 adaptor proteins (MyD88 and IRAK1) and NF-κB p65. ", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "Results:\nIL-36α and IL-36γ significantly enhanced the secretion of IL-6 and CXC chemokines (CXCL1, CXCL2, and CXCL8) by SEMFs. The combination of IL-36α/γ and IL-17A or of IL-36α/γ and tumor necrosis factor-α showed a synergistic effect on the induction of IL-6 and CXC chemokines. The mRNA expression of proinflammatory mediators induced by IL-36α and/or IL-36γ was significantly suppressed by transfection of siRNA for MyD88 or IRAK1. Both inhibitors of mitogen activated protein kinases and siRNAs specific for NF-κBp65 significantly reduced the expression of IL-6 and CXC chemokines induced by IL-36α and/or IL-36γ.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "Conclusion:\nThese results suggest that IL-36α and IL-36γ contribute to gut inflammation through the induction of proinflammatory mediators. ", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_6_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Thesis or Dissertation", "subitem_description_type": "Other"}]}, "item_6_description_69": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "平成27年度", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_71": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第750号"}]}, "item_6_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Frontiers Media", "subitem_publisher_language": "en"}]}, "item_6_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "26442271", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.3389/fmed.2015.00069"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3389/fmed.2015.00069", "subitem_relation_type_select": "DOI"}}]}, "item_6_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2296-858X", "subitem_source_identifier_type": "EISSN"}]}, "item_6_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "KANDA, Toshihiro", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "fmed-02-00069.pdf", "filesize": [{"value": "6.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 6600000.0, "url": {"label": "fmed-02-00069", "objectType": "fulltext", "url": "https://shiga-med.repo.nii.ac.jp/record/3125/files/fmed-02-00069.pdf"}, "version_id": "2a721f8a-5012-428e-a210-6a910fb032f9"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Interleukin(IL)-36α and IL-36γ induce proinflammatory mediators from human colonic subepithelial myofibroblasts.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Interleukin(IL)-36α and IL-36γ induce proinflammatory mediators from human colonic subepithelial myofibroblasts.", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "11", "path": ["37"], "permalink_uri": "http://hdl.handle.net/10422/00012284", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-05-10"}, "publish_date": "2017-05-10", "publish_status": "0", "recid": "3125", "relation": {}, "relation_version_is_last": true, "title": ["Interleukin(IL)-36α and IL-36γ induce proinflammatory mediators from human colonic subepithelial myofibroblasts."], "weko_shared_id": -1}
Interleukin(IL)-36α and IL-36γ induce proinflammatory mediators from human colonic subepithelial myofibroblasts.
http://hdl.handle.net/10422/00012284
http://hdl.handle.net/10422/0001228416c3fee8-78ef-470c-a828-8f6bb65e525c
名前 / ファイル | ライセンス | アクション |
---|---|---|
fmed-02-00069 (6.6 MB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
---|---|---|---|---|---|---|---|---|
公開日 | 2017-05-10 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Interleukin(IL)-36α and IL-36γ induce proinflammatory mediators from human colonic subepithelial myofibroblasts. | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 |
KANDA, Toshihiro
× KANDA, Toshihiro
|
|||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Background: Interleukin (IL)-36 cytokines are recently reported member of the IL-1 cytokine family. However, there is little information regarding the association between IL-36 cytokines and gut inflammation. In the present study, we investigated the biological activity of IL-36α and IL-36γ using human colonic subepithelial myofibroblasts (SEMFs). |
|||||||
言語 | en | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Methods: The mRNA expression and the protein expression of target molecules in SEMFs were evaluated using real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The intracellular signaling of IL-36 cytokines was analyzed using Western blot analysis and small interfering RNAs (siRNAs) specific for MyD88 adaptor proteins (MyD88 and IRAK1) and NF-κB p65. |
|||||||
言語 | en | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Results: IL-36α and IL-36γ significantly enhanced the secretion of IL-6 and CXC chemokines (CXCL1, CXCL2, and CXCL8) by SEMFs. The combination of IL-36α/γ and IL-17A or of IL-36α/γ and tumor necrosis factor-α showed a synergistic effect on the induction of IL-6 and CXC chemokines. The mRNA expression of proinflammatory mediators induced by IL-36α and/or IL-36γ was significantly suppressed by transfection of siRNA for MyD88 or IRAK1. Both inhibitors of mitogen activated protein kinases and siRNAs specific for NF-κBp65 significantly reduced the expression of IL-6 and CXC chemokines induced by IL-36α and/or IL-36γ. |
|||||||
言語 | en | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Conclusion: These results suggest that IL-36α and IL-36γ contribute to gut inflammation through the induction of proinflammatory mediators. |
|||||||
言語 | en | |||||||
学位名 | ||||||||
言語 | ja | |||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 14202 | |||||||
言語 | ja | |||||||
学位授与機関名 | 滋賀医科大学 | |||||||
学位授与年度 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 平成27年度 | |||||||
言語 | ja | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2016-03-10 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第750号 | |||||||
書誌情報 |
en : Frontiers in Medicine 巻 2, p. 69, 発行日 2015-09-22 |
|||||||
出版者 | ||||||||
言語 | en | |||||||
出版者 | Frontiers Media | |||||||
著者版フラグ | ||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
ISSN | ||||||||
収録物識別子タイプ | EISSN | |||||||
収録物識別子 | 2296-858X | |||||||
PMID | ||||||||
識別子タイプ | PMID | |||||||
関連識別子 | 26442271 | |||||||
DOI | ||||||||
識別子タイプ | DOI | |||||||
関連識別子 | https://doi.org/10.3389/fmed.2015.00069 | |||||||
関連名称 | 10.3389/fmed.2015.00069 | |||||||
資源タイプ | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Thesis or Dissertation |