Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
Neocortical-hippocampal dynamics of working memory in healthy and diseased brain states based on functional connectivity
Entity
UAM. Departamento de Psicología BásicaPublisher
Frontiers Research FoundationDate
2012-03Citation
10.3389/fnhum.2012.00036
Frontiers in Human Neuroscience 6 (2012): 1-14
ISSN
1662-5161 (print)DOI
10.3389/fnhum.2012.00036Funded by
This work was supported by a research grant from the Spanish Ministry of Science and Innovation (Grant PSI2010–16742) to Pablo Campo. Claudia Poch was supported by Spanish Ministry of Science and Education (AP2009–4131). Pablo Campo was supported by a Ramon y Cajal Fellowship from the Spanish Ministry of Science and Innovation (RYC-2010–05748)Project
Gobierno de España. PSI2010–16742; Gobierno de España. AP2009–4131; Gobierno de España. RYC-2010–05748Editor's Version
http://dx.doi.org/10.3389/fnhum.2012.00036Subjects
Functional connectivity; Effective connectivity; Working memory; Hippocampus; Medial temporal lobe; Epilepsy; Dementia; Schizophrenia; PsicologíaRights
© 2012 Poch and CampoAbstract
Working memory (WM) is the ability to transiently maintain and manipulate internal representations beyond its external availability to the senses. This process is thought to support high level cognitive abilities and been shown to be strongly predictive of individual intelligence and reasoning abilities. While early models of WM have relied on a modular perspective of brain functioning, more recent evidence suggests that cognitive functions emerge from the interactions of multiple brain regions to generate large-scale networks. Here we will review the current research on functional connectivity of WM processes to highlight the critical role played by neural interactions in healthy and pathological brain states. Recent findings demonstrate that WM abilities are not determined solely by local brain activity, but also rely on the functional coupling of neocortical-hippocampal regions to support WM processes. Although the hippocampus has long been held to be important for long-term declarative memory, recent evidence suggests that the hippocampus may also be necessary to coordinate disparate cortical regions supporting the periodic reactivation of internal representations in WM. Furthermore, recent brain imaging studies using connectivity measures, have shown that changes in cortico-limbic interactions can be useful to characterize WM impairments observed in different neuropathological conditions. Recent advances in electrophysiological and neuroimaging techniques to model network activity has led to important insights into how neocortical and hippocampal regions support WM processes and how disruptions along this network can lead to the memory impairments commonly reported in many neuropathological populations
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Google Scholar:Poch, Claudia
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Campo Martínez-Lage, Pablo
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