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Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering
journal contribution
posted on 2010-01-08, 00:00 authored by Xiaojian Wang, Yuncang Li, Peter HodgsonPeter Hodgson, Cui'E WenPorous titanium (Ti) and Ti alloys are important scaffold materials for bone tissue engineering. In the present study, a new type of porous Ti alloy scaffold with biocompatible alloying elements, that is, niobium (Nb) and zirconium (Zr), was prepared by a space-holder sintering method. This porous TiNbZr scaffold with a porosity of 69% exhibits a mechanical strength of 67MPa and an elastic modulus of 3.9GPa, resembling the mechanical properties of cortical bone. To improve the osteoconductivity, a calcium phosphate (Ca/P) coating was applied to the surface of the scaffold using a biomimetic method. The biocompatibility of the porous TiNbZr alloy scaffold before and after the biomimetic modification was assessed using the SaOS2 osteoblast–like cells. Cell culture results indicated that the porous TiNbZr scaffold is more favorable for cell adhesion and proliferation than its solid counterpart. By applying a Ca/P coating, the cell proliferation rate on the Ca/P-coated scaffold was significantly improved. The results suggest that high-strength porous TiNbZr scaffolds with an appropriate osteoconductive coating could be potentially used for bone tissue engineering application.
History
Journal
Tissue engineering : part AVolume
16Issue
1Pagination
309 - 316Publisher
Mary Ann Liebert PublishersLocation
New Rochelle, N.Y.Publisher DOI
ISSN
1937-3341eISSN
1937-335XLanguage
engNotes
Online Publication Date: September 28, 2009Publication classification
C1 Refereed article in a scholarly journalCopyright notice
2010, Mary Ann Liebert PublishersUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineTechnologyCell & Tissue EngineeringCell BiologyEngineering, BiomedicalMaterials Science, BiomaterialsEngineeringMaterials ScienceBIOACTIVE TITANIUM METALGRAFT SUBSTITUTESMECHANICAL-PROPERTIESCALCIUM-PHOSPHATEINGROWTHTANTALUMPERFORMANCEIMPLANTSPOROSITYSURFACE
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