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Early inflammatory and myogenic responses to resistance exercise in the elderly
journal contribution
posted on 2012-09-01, 00:00 authored by J Mathers, M Farnfield, Andrew GarnhamAndrew Garnham, M Caldow, David Cameron-Smith, J PeakeIntroduction and Methods: This study compared changes in myokine and myogenic genes following resistance exercise (3 sets of 12 repetitions of maximal unilateral knee extension) in 20 elderly men (67.8 ± 1.0 years) and 15 elderly women (67.2 ± 1.5 years). Results: Monocyte chemotactic protein (MCP)-1, macrophage inhibitory protein (MIP)-1β, interleukin (IL)-6 and MyoD mRNA increased significantly (P < 0.05), whereas myogenin and myostatin mRNA decreased significantly after exercise in both groups. Macrophage-1 (Mac-1) and MCP-3 mRNA did not change significantly after exercise in either group. MIP-1β, Mac-1 and myostatin mRNA were significantly higher before and after exercise in men compared with women. In contrast, MCP-3 and myogenin mRNA were significantly higher before and after exercise in the women compared with the men. Conclusions: In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury.
History
Journal
Muscle and NerveVolume
46Issue
3Pagination
407 - 412Publisher
John Wiley & Sons, Inc.Location
Hoboken N.J.Publisher DOI
ISSN
0148-639XeISSN
1097-4598Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2012, John Wiley & Sons, Inc.Usage metrics
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No categories selectedKeywords
agingregenerationmyokinemuscle damageinflammationScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeurosciencesNeurosciences & NeurologyINFLUENCE POSTEXERCISE INDEXESHUMAN SKELETAL-MUSCLEMONOCYTE CHEMOTACTIC PROTEIN-3POINT-COUNTERPOINT ESTROGENMYOSTATIN GENE-EXPRESSIONSEX DO\/DOECCENTRIC EXERCISEOLDER-ADULTSMYOFIBER HYPERTROPHYPOSTMENOPAUSAL WOMEN
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