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Severe chronic renal failure in association with oxycodone addiction: a new form of fibrillary glomerulopathy
journal contribution
posted on 2002-08-01, 00:00 authored by P Hill, Karen DwyerKaren Dwyer, T Kay, B MurphyA number of well-documented renal lesions have been associated with intravenous drug use. Recently, investigators reported three cases of granulomatous glomerulonephritis in association with intravenous injection of oxycodone suppositories. We report 2 patients with similar glomerular pathology who presented with chronic renal failure. However, we also highlight the widespread tubulointerstitial involvement in this renal lesion. The fibrillar deposits seen within the glomeruli and extensively within tubular basement membranes on electron microscopy do not have the staining characteristics of amyloid and are not associated with immunoglobulin (Ig) deposition. Is this a new form of non-Ig-associated fibrillary glomerulopathy with its pathogenesis linked to some component of the oxycodone suppositories? One of the patients had a history of narcotic addiction but denied intravenous injection of suppositories. In both patients there was progressive deterioration of renal function with 1 patient requiring dialysis within 3 months of initial presentation. Copyright 2002, Elsevier Science (USA). All rights reserved.
History
Journal
Human pathologyVolume
33Issue
8Pagination
783 - 787Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0046-8177Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2002, Elsevier ScienceUsage metrics
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