bramwell-transmissablecancers-2020.pdf (1.34 MB)
Transmissible cancers in an evolutionary perspective
journal contribution
posted on 2020-07-24, 00:00 authored by Antoine Marie Dujon, R A Gatenby, Georgina BramwellGeorgina Bramwell, N MacDonald, E Dohrmann, Nynke RavenNynke Raven, Aaron SchultzAaron Schultz, R Hamede, A L Gérard, M Giraudeau, F Thomas, Beata UjvariBeata UjvariInter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.
History
Journal
iScienceVolume
23Issue
7Article number
101269Pagination
1 - 12Publisher
Cell PressLocation
Cambridge, Mass.Publisher DOI
Link to full text
eISSN
2589-0042Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalUsage metrics
Keywords
Science & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsSOFT-SHELL CLAMFACIAL TUMOR DISEASETASMANIAN DEVILVENEREAL TUMORNEOPLASTIC DISEASESINFECTIOUS-DISEASESHEMIC NEOPLASIAMYA-ARENARIARESISTANCEGENOMEBiological SciencesCancerEvolutionary BiologyEvolutionary EcologyEvolutionary Biology
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