Hypoxic ischemic encephalopathy : diagnosis, hypothermia treatment and outcome
Author: Hallberg, Boubou
Date: 2010-05-21
Location: Föreläsningssalen Q9 Månen, Alfred Nobels Allé 8, Karolinska Universitets Sjukhuset Huddinge
Time: 09.00
Department: Institutionen för klinisk vetenskap / Department of Clinical Sciences
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thesis.pdf (2.031Mb)
Abstract
Hypothermia treatment (HT) is now proven to be neuroprotective, is
associated with favourable outcomes, and is considered as the standard of
care for moderate to severe hypoxic ischemic encephalopathy (HIE). The
treatment should be regionalized with a minimum of ten treated infants
per year with regard to securing patient safety, staff training,
development and future research. Still, many infants are in desperate
need of additional therapies for neuronal rescue to reduce the risk of
death or severe handicap. The implementation of a national HT register
has revealed differences in the regional incidence of HT, indicating that
infants that could benefit from HT do not receive this therapy.
All of the following main findings in this thesis have lead to changes in clinical practice:
* Prevention of HIE by using fetal scalp blood lactate combined with fetal heart rate/cardiotocogram during labour is feasible. We consider fetal scalp blood lactate measurement at the cut-off level at of 4.8 mmol/L (75th percentile) to be a better predictive marker for hypoxia-ischemia during labour than pH. The predictive capacity is higher and the sampling technique is easier, with a high success rate.
* Early induction of HT is feasible prior to transport. Earlier start of HT could mean that the neuroprotective effect is more beneficial. However, passive cooling results in a high risk of excessive cooling and should be used with caution, i.e. temperature should be monitored continuously and personnel should be trained in HT induction at all delivery units.
* Moderate HT alters the predictive value of amplitude integrated EEG (aEEG) in asphyxiated infants. These findings are of central value in the context of early prognosis and in decision making for withdrawal or continuation of intensive care treatment.
* The overwhelming majority of infants with moderate neonatal encephalopathy (NE) have major and/or cognitive disabilities at long-term follow-up. Most children with cerebral paresis (CP) also have cognitive dysfunctions. This is of great importance for early therapeutic interventions, allocation of habilitation resources and support for the educational system.
In conclusion our findings gives an additional diagnostic tool in prevention of HIE, gives important information on implementation of hypothermia treatment and emphasis the necessity of long-term follow-up in encephalopatic infants.
All of the following main findings in this thesis have lead to changes in clinical practice:
* Prevention of HIE by using fetal scalp blood lactate combined with fetal heart rate/cardiotocogram during labour is feasible. We consider fetal scalp blood lactate measurement at the cut-off level at of 4.8 mmol/L (75th percentile) to be a better predictive marker for hypoxia-ischemia during labour than pH. The predictive capacity is higher and the sampling technique is easier, with a high success rate.
* Early induction of HT is feasible prior to transport. Earlier start of HT could mean that the neuroprotective effect is more beneficial. However, passive cooling results in a high risk of excessive cooling and should be used with caution, i.e. temperature should be monitored continuously and personnel should be trained in HT induction at all delivery units.
* Moderate HT alters the predictive value of amplitude integrated EEG (aEEG) in asphyxiated infants. These findings are of central value in the context of early prognosis and in decision making for withdrawal or continuation of intensive care treatment.
* The overwhelming majority of infants with moderate neonatal encephalopathy (NE) have major and/or cognitive disabilities at long-term follow-up. Most children with cerebral paresis (CP) also have cognitive dysfunctions. This is of great importance for early therapeutic interventions, allocation of habilitation resources and support for the educational system.
In conclusion our findings gives an additional diagnostic tool in prevention of HIE, gives important information on implementation of hypothermia treatment and emphasis the necessity of long-term follow-up in encephalopatic infants.
List of papers:
I. Kruger K, Hallberg B, Blennow M, Kublickas M, Westgren M (1999). "Predictive value of fetal scalp blood lactate concentration and pH as markers of neurologic disability." Am J Obstet Gynecol 181(5 Pt 1): 1072-8
Pubmed
II. Hallberg B, Olson L, Bartocci M, Edqvist I, Blennow M (2009). "Passive induction of hypothermia during transport of asphyxiated infants: a risk of excessive cooling." Acta Paediatr 98(6): 942-6
Pubmed
III. Hallberg B, Grossmann K, Bartocci M, Blennow M (2010). "The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment." Acta Paediatr 99(4): 531-6. Epub 2009 Dec 24
Pubmed
IV. Lindström K, Hallberg B, Blennow M, Wolff K, Fernell E, Westgren M (2008). "Moderate neonatal encephalopathy: pre- and perinatal risk factors and long-term outcome" Acta Obstet Gynecol Scand 87(5): 503-9
Pubmed
I. Kruger K, Hallberg B, Blennow M, Kublickas M, Westgren M (1999). "Predictive value of fetal scalp blood lactate concentration and pH as markers of neurologic disability." Am J Obstet Gynecol 181(5 Pt 1): 1072-8
Pubmed
II. Hallberg B, Olson L, Bartocci M, Edqvist I, Blennow M (2009). "Passive induction of hypothermia during transport of asphyxiated infants: a risk of excessive cooling." Acta Paediatr 98(6): 942-6
Pubmed
III. Hallberg B, Grossmann K, Bartocci M, Blennow M (2010). "The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment." Acta Paediatr 99(4): 531-6. Epub 2009 Dec 24
Pubmed
IV. Lindström K, Hallberg B, Blennow M, Wolff K, Fernell E, Westgren M (2008). "Moderate neonatal encephalopathy: pre- and perinatal risk factors and long-term outcome" Acta Obstet Gynecol Scand 87(5): 503-9
Pubmed
Issue date: 2010-04-30
Rights:
Publication year: 2010
ISBN: 978-91-7409-907-2
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