The Impact of Beta-blockade on Right Ventricular Function in Mitral Regurgitation
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Other Title
Authors
Hongning, Yin
Stewart, Ralph A.
Whalley, Gillian
Stewart, Ralph A.
Whalley, Gillian
Author ORCID Profiles (clickable)
Degree
Grantor
Date
2014-04
Supervisors
Type
Journal Article
Ngā Upoko Tukutuku (Māori subject headings)
Keyword
mitral regurgitation
beta-blockers
Tei index
echocardiography
Doppler
beta-blockers
Tei index
echocardiography
Doppler
ANZSRC Field of Research Code (2020)
Citation
Hongning, Y., Stewart, R. A., and Whalley, G. A. (2014). The impact of beta-blockade on right ventricular function in mitral regurgitation. Heart, Lung and Circulation, 23, pp.378-380.
Abstract
Background
Although mitral regurgitation (MR) results in left ventricular (LV) volume overload, right ventricular (RV) function may also be impaired. We investigated the influence of short-term beta-blockade on RV function in patients with moderate-severe MR.
Methods
Twenty-six patients were randomised in a cross-over design to receive two weeks of beta-blockade or placebo. Echocardiography was performed at baseline and at the end of the treatment periods. Measure- ments included: RV ejection fraction (RVEF) tricuspid annular motion and Tei index.
Results
No differences in mean RVEF (64.0 ± 6.0 v 67.0 ± 8.0%, p = 0.3), tricuspid annular motion (13.5 ± 3.0 v 14.7 + 2.9 cm/s, p = 0.5), or median Tei index (0.61 (0.54, 0.88) v 0.59 (0.54, 0.74), p = 0.8) were observed between placebo and metoprolol, despite significantly longer cardiac time intervals. Tei index under both conditions was significantly reduced.
Conclusions
Short-term treatment with a beta-blocker did not influence RV function in these patients. Interestingly, the RV Tei index was high suggesting significant RV dysfunction despite normal RVEF.
Publisher
Elsevier Inc
Permanent link
Link to ePress publication
DOI
http://dx.doi.org/10.1016/j.hlc.2013.10.090
Copyright holder
Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)
Copyright notice
© 2013 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)