175 years of bilirubin testing : ready for point-of-care?
Article [Version of Record]
Is part of
Advanced healthcare materials ; vol. 12, no. 18.Publisher(s)
WileyAffiliation
Keywords
Abstract(s)
Bilirubin was first detected in blood in 1847 and since then has become one of
the most widely used biomarkers for liver disease. Clinical routine bilirubin
testing is performed at the hospital laboratory, and the gold standard
colorimetric test is prone to interferences. The absence of a bedside test for
bilirubin delays critical clinical decisions for patients with liver disease. This
clinical care gap has motivated the development of a new generation of
bioengineered point-of-care bilirubin assays. In this Perspective, recently
developed bilirubin assays are critically discussed, and their translational
potential evaluated.