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Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization
journal contribution
posted on 2023-08-24, 05:32 authored by J Du, L Fan, Joselito RazalJoselito Razal, S Chen, H Zhang, H Yang, H Li, Jingliang LiJingliang LiTissue engineered skin and its substitutes have a promising future in wound healing. However, enabling fast formation of blood vessels during the wound healing process is still a huge challenge to the currently available wound substitutes. In this work, active mesoporous bioglass nanoparticles with a high specific surface area and doped with strontium (Sr) were fabricated for rapid microvascularization and wound healing. The as-prepared bioglass nanoparticles with Sr ions significantly promoted the proliferation of fibroblasts and microvascularization of human umbilical vein endothelial cells in vitro. Silk fibroin sponges encapsulating the nanoparticles accelerated wound healing by promoting the formation of blood vessels and epithelium in vivo. This work provides a strategy for the design and development of active biomaterials for enhancing wound healing by rapid vascularization and epithelial reconstruction.
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Journal
Journal of Materials Chemistry BLocation
EnglandPublisher DOI
ISSN
2050-750XeISSN
2050-7518Language
EnglishPublication classification
C1 Refereed article in a scholarly journalPublisher
ROYAL SOC CHEMISTRYUsage metrics
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Keywords
Science & TechnologyTechnologyMaterials Science, BiomaterialsMaterials ScienceANTIBACTERIALANGIOGENESISHYDROGELSSYSTEM40 Engineering4003 Biomedical EngineeringNanotechnologyBioengineering3403 Macromolecular and materials chemistry4003 Biomedical engineering4004 Chemical engineeringBiomedical Engineering not elsewhere classifiedMacromolecular and Materials Chemistry not elsewhere classified
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