Carbon nanotubes gathered onto silica particles lose their biomimetic properties with the cytoskeleton becoming biocompatible
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Identificadores
URI: http://hdl.handle.net/10902/11931DOI: 10.2147/IJN.S141794
ISSN: 1178-2013
ISSN: 1176-9114
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González Domínguez, Elena; Iturrioz Rodríguez, Nerea; Padín González, Esperanza; Villegas Sordo, Juan Carlos; García Hevia, Lorena; Pérez Lorenzo, Moisés; Parak, Wolfgang J.; Correa Duarte, Miguel A.; López Fanarraga, MónicaFecha
2017Derechos
Atribución-NoComercial 3.0 España
Publicado en
International Journal of Nanomedicine, 2017, 12, 6317-6328
Editorial
Dove Medical Press
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Resumen/Abstract
Carbon nanotubes (CNTs) are likely to transform the therapeutic and diagnostic fields in biomedicine during the coming years. However, the fragmented vision of their side effects and toxicity in humans has proscribed their use as nanomedicines. Most studies agree that biocompatibility depends on the state of aggregation/dispersion of CNTs under physiological conditions, but conclusions are confusing so far. This study designs an experimental setup to investigate the cytotoxic effect of individualized multiwalled CNTs compared to that of identical nanotubes assembled on submicrometric structures. Our results demonstrate how CNT cytotoxicity is directly dependent on the nanotube dispersion at a given dosage. When CNTs are gathered onto silica templates, they do not interfere with cell proliferation or survival becoming highly compatible. These results support the hypothesis that CNT cytotoxicity is due to the biomimetics of these nanomaterials with the intracellular nanofilaments. These findings provide major clues for the development of innocuous CNT-containing nanodevices and nanomedicines.
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