The Different Microbial Etiology of Prosthetic Joint Infections According to Route of Acquisition and Time After Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms
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Benito, Natividad; Mur, Isabel; Ribera, Alba; Soriano, Alex; Rodríguez-Pardo, Dolors; Sorlí, Luisa; Cobo, Javier; Fernández Sampedro, Marta; Toro, María Dolores del; Guío, Laura; Praena, Julia; Bahamonde, Alberto; Riera, Melchor; Esteban, Jaime; Mirena Baraia-Etxaburu, Josu; Martínez-Alvarez, Jesús; Jover-Sáenz, Alfredo; Dueñas, Carlos; Ramos, Antonio; [et al.]Fecha
2019Derechos
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
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J Clin Med
. 2019 May 13;8(5):673
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MDPI AG
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Palabras clave
Prosthetic Joint Infections
Microbial Etiology
Classification Schemes For Prosthetic Joint Infections
Antimicrobial Empirical Treatment
Multidrug-Resistant Organisms
Resumen/Abstract
The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and "positive intraoperative cultures" (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2-3 months, 4-12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
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