The Multiple Faces of MNT and Its Role as a MYC Modulator
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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license.
Publicado en
Cancers (Basel)
. 2021 Sep 18;13(18):4682
Editorial
MDPI
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Palabras clave
MNT
MYC
MAX
REL
Transcriptional regulation
Proliferation
Cancer
Resumen/Abstract
MNT is a crucial modulator of MYC, controls several cellular functions, and is activated
in most human cancers. It is the largest, most divergent, and most ubiquitously expressed protein
of the MXD family. MNT was first described as a MYC antagonist and tumor suppressor. Indeed,
10% of human tumors present deletions of one MNT allele. However, some reports show that MNT
functions in cooperation with MYC by maintaining cell proliferation, promoting tumor cell survival,
and supporting MYC-driven tumorigenesis in cellular and animal models. Although MAX was
originally considered MNT?s obligate partner, our recent findings demonstrate that MNT also works
independently. MNT forms homodimers and interacts with proteins both outside and inside of
the proximal MYC network. These complexes are involved in a wide array of cellular processes,
from transcriptional repression via SIN3 to the modulation of metabolism through MLX as well as
immunity and apoptosis via REL. In this review, we discuss the present knowledge of MNT with a
special focus on its interactome, which sheds light on the complex and essential role of MNT in cell
biology.
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